Ithimba lososayensi base-Polish eliholwa ngu-Magdalena Winkel wase-Adam Mickiewicz University libuyekeze inhlanganisela yezinto eziphilayo ezibizwa ngokuthi i-glycoalkaloids (etholakala kumazambane kanye nenani lemifino ye-nightshade) ukuze kuboniswe ikhono lawo lokwelapha i-oncology.
Imiphumela yocwaningo ishicilelwe kuphephabhuku iFrontiers in Pharmacology, kubika i-Android-Robot portal.
UWinkel nozakwabo bagxile kuma-glycoalkaloid amahlanu—i-solanine, i-chaconine, i-solasonine, i-solamargine, ne-tomatine—atholakala ezitshalweni ezingahluziwe zezitshalo zomndeni we-nightshade.
Izitshalo eziningi kulo mndeni zinobuthi (ikakhulukazi ngenxa yama-alkaloid eziwakhiqizayo ukuze zixoshe izilwane), kodwa umthamo ofanele ungashintsha ushevu ube umuthi: uma ososayensi bethola umthamo ophephile wokwelapha wama-alkaloid, angaba amathuluzi omtholampilo anamandla.
Ama-Glycoalkaloids, ikakhulukazi, avimbela ukukhula kwamangqamuzana omdlavuza futhi angakhuthaza ukufa kwawo. I-Solanine imisa ukuguqulwa kwamakhemikhali athile angaba umdlavuza abe ama-carcinogens emzimbeni futhi ivimbele i-metastasis. I-Chaconine inezindawo zokulwa nokuvuvukala futhi ingaphatha i-sepsis. I-Solamargin, etholakala kakhulu kuma-eggplant, imisa ukwanda kwamangqamuzana omdlavuza wesibindi. Futhi i-tomatine isekela ukulawulwa komzimba komjikelezo wamaseli ukuze ukwazi ukubulala amangqamuzana omdlavuza.
"Kuzodingeka ucwaningo olwengeziwe ukuze kutholakale ukuthi lokhu okungenzeka kungenziwa kanjani emisebenzini yomtholampilo," uWinkel nethimba lakhe baphawula, "ukuqonda kangcono izindlela zokwenza ama-glycoalkaloids kuyodingeka futhi konke ukukhathazeka okungase kube nokuphepha kuyodingeka kucatshangelwe ngokucophelela. ngaphambi kokuba iziguli zizuze emithini elwa nomdlavuza ngokuqondile emibhedeni."