Ucwaningo olusha oluvela eNyuvesi yaseNorth Carolina (e-USA) lubonisa indlela ephindaphindekayo yokufunda ukuxhumana kwamaselula phakathi kwezinhlobo ezihlukene zamaseli ezitshalo "ngokuphrinta okuphilayo" lawa maseli kusetshenziswa iphrinta ye-3D. Ingosi yezindaba.ncsu.edu.
Ukutadisha ukuthi amaseli ezitshalo axhumana kanjani namanye kanye nendawo yawo kuyisihluthulelo sokuqonda kangcono ukusebenza kwamaseli ezitshalo futhi kungaholela ezinhlotsheni zezitshalo ezingcono.
Abacwaningi baphrinta amaseli ezitshalo eziyimodeli I-Arabidopsis thaliana kanye nesoya, ukuze bangagcini nje ngokufunda ukuthi amangqamuzana ezitshalo ayasinda yini ku-bioprinting—futhi isikhathi esingakanani—kodwa futhi nokuqonda ukuthi athola futhi aguqule ubunikazi bawo kanye nokusebenza kwawo.
Inqubo ye-3D bioprinting yamaseli ezitshalo iyafana mshini nokusebenzisa uyinki wokuphrinta noma ipulasitiki, enokulungiswa okumbalwa okudingekayo.
Esikhundleni soyinki wokuphrinta we-3D, ososayensi basebenzisa “i-bio-ink,” noma amaseli ezitshalo eziphilayo. Imishini kuzo zombili izinqubo iyafana, ngaphandle komehluko ambalwa ophawulekayo wamaseli ezitshalo: isihlungi se-ultraviolet esisetshenziselwa ukugcina ubunyumba, nama-printheads amaningi ukuze aphrinte kusuka ku-biomaterials ehlukene ngesikhathi esisodwa.
Amaseli ezitshalo aphilayo angenazo izindonga zamangqamuzana, noma ama-protoplast, anyatheliswa nge-bioprint kanye nezakhi, ama-hormone okukhula, kanye ne-agent eqinisayo ebizwa ngokuthi i-agarose, isakhi esisekelwe olwandle. I-Agarose isiza ukunikeza amandla eseli.
Ucwaningo lubonise ukuthi ngaphezu kwesigamu samaseli e-3D bioprinted ayesebenza futhi ahlukaniswa ngokuhamba kwesikhathi ukuze akhe amakoloni amancane.
Abacwaningi baphinde banyathelisa amangqamuzana ngamanye ukuze babone ukuthi angakwazi yini ukukhiqiza kabusha noma ukuhlukanisa futhi ande. Imiphumela yabonisa ukuthi amaseli ezimpande nama-shoot cell I-Arabidopsis badinga inhlanganisela ehlukene yezakhamzimba ukuze babe nempilo enhle.
Ngaleso sikhathi, ngaphezu kwama-40% amaseli e-soya embryonic ahlala esebenza emasontweni amabili ngemuva kwe-bioprinting futhi ahlukaniswa ngokuhamba kwesikhathi ukuze akhe ama-microcell.
I-3D bioprinting ingase ibe usizo ekutadisheni ukuvuselelwa kwamaselula ezitshalweni ezitshaliwe.
Amaseli ezimpande I-Arabidopsis kanye namaseli e-embryonic kabhontshisi wesoya aziwa ngokwanda kwamazinga aphezulu kanye nokuntuleka kokuhlonza okungaguquki. Ngamanye amazwi, njengama-stem cell esilwane noma omuntu, lawa maseli angaba izinhlobo ezahlukene zamaseli.
Amaseli e-bioprinted angathatha ubunikazi bama-stem cells; ziyahlukanisa, zikhule, futhi ziveze izakhi zofuzo ezithile.
Lolu cwaningo lubonisa amandla anamandla okusebenzisa i-3D bioprinting ukuhlonza izinhlanganisela ezifanele ezidingekayo ukuze kugcinwe ukusebenza kwamangqamuzana ezitshalo nokuxhumana endaweni elawulwayo.
Ucwaningo olushicilelwe kujenali Ukuthuthukiswa Kwezesayensi.