Ezilwaneni, ukulimala kwe-DNA kungaholela ekwakhekeni kwezimila. Nakuba izitshalo zihlala isikhathi eside ngaphandle komdlavuza, ukukhula kwazo kuhlale kuvinjwa yizinto eziningi zemvelo, njengemisebe, usawoti, izinsimbi ezinzima kanye nezikhukhula, okungaholela ekulimaleni kwe-DNA futhi kunciphise isivuno.
Izitshalo zizivikela kanjani ekulimaleni kwe-DNA?
Ithimba labacwaningi abavela ku-Qingdao Institute of Bioenergy and Bioprocessor Technology (QIBEBT) ye-Chinese Academy of Sciences (CAS) linikeza impendulo kulo mbuzo. Bakhomba i-protein complex ebizwa nge-MAC, ebalulekile ekuphenduleni kwezitshalo emonakalweni we-DNA, kubika Ingosi ye-Phys.org.
Umsebenzi wabo washicilelwa kumagazini i-Plant Physiology ngoNovemba 4.
Abacwaningi bathola ukuthi izitshalo ezingenazo i-protein ye-MAC esebenzayo zibonise ukukhubazeka kokukhula futhi zonakaliswe kalula yi-methyl methanesulfonate (MMS), ikhemikhali ebangela ukuphuka kwe-DNA.
Baphinde bathola ukuthi ukubekezelelwa okuphezulu kwe-boron kwalezi zinguquko ze-MAC kwehlisiwe. I-boron ephezulu enhlabathini ilimaza isivuno sezitshalo kanye nezakhamzimba ekudleni.
Izinga le-MAC5A protein (ingxenye ye-MAC complex) lalilawulwa yi-26S proteasome (26SP), umshini wamangqamuzana odingekayo ukuze kucutshungulwe amaprotheni ngokusebenzisana okuqondile.
Ngosizo lwe-biochemical kanye Ngokuhlaziya izakhi zofuzo, abacwaningi bahlonze ama-protein complexes amabili asebenza ndawonye ukuze avikele izitshalo emonakalweni we-DNA obangelwa yi-methyl methanesulfonate ne-boron ephezulu.
Lolu cwaningo lwembula izindlela zamangqamuzana zokuthi izitshalo zisabela kanjani ekulimaleni kwe-DNA futhi lwanikeza isihluthulelo esisha sokuthuthukisa ukukhiqizwa kwezitshalo kanye nekhwalithi yokudla.