Ososayensi baseNyuvesi yaseHiroshima bathole inhlanganisela entsha ku-broccoli namanye amakhabishi engasiza ukulwa nezinhlobo ezithile zomdlavuza.
I-DIM, noma i-3,3′-diindolylmethane, ibangela ukufa kweseli elilawulwayo kanye nokugaywa kabusha kwezingxenye zamaselula kumbiliso ye-fission. Ukuthi indlela yomonakalo odalwe yi-DIM iyalondolozwa yini kubantu okwamanje akwaziwa.
"Sithole ukuthi i-chemical compound DIM idala umsebenzi omusha wezinto eziphilayo olimaza ulwelwesi lwenuzi kumvubelo ye-fission," kusho u-Ueno, uprofesa ohlangene e-Hiroshima Healthy Aging Research Center e-Graduate School of Integrated Life Sciences e-Hiroshima University.
“Ubuqotho bolwelwesi lwenuzi bubalulekile empilweni yomuntu,” kusho u-Ueno. “Izinguquko ezishintsha izakhi zofuzo ezidala ukukhubazeka kulwelwesi lwenuzi zisheshisa ukuguga. Ulwelwesi lwenuzi nalo luyaqhuma futhi lulungiswe ngesikhathi sokufuduka kwamangqamuzana omdlavuza.”
Ingxenye yenqubo yokulungisa iseli ibizwa ngokuthi i-autophagy noma "ukuzidla." Lena indlela yokuwohloka kwezingxenye zamangqamuzana, lapho ingqamuzana lizodla izingxenye zalo zangaphakathi ukuze lilondoloze amandla futhi lenze izinqubo ezibalulekile.
U-Ueno uphinde waphawula ukuthi i-autophagy ihlotshaniswa nokuguga kanye nezifo ezihlobene nobudala. Uma ingqamuzana linesici, liyafa ngenqubo yokufa ehleliwe ebizwa ngokuthi i-apoptosis. Izidakamizwa eziningi ze-cytotoxic anticancer zisebenza ngokufaka i-apoptosis, ngakho-ke ukukwazi ukulawula le nqubo kungasiza ekulondolozeni nasekuthuthukiseni impilo yabantu, kusho u-Ueno.
“Imiphumela yethu isikisela ukuthi imvilophu yenuzi ingase ibe enye yezinhloso zokuqala ze-DIM,” kusho umlobi wephepha u-Parvaneh Emami, umfundi oneziqu eSikoleni Seziqu Sezifundo Zokuphila Ezihlanganisiwe e-Hiroshima University.
Lokhu okutholakele kwakhela embikweni wangaphambilini ovela ethimbeni labacwaningi eJalimane elithole ukuthi ukugxila okuphezulu kwe-DIM kwandisa isikhathi sokuphila se-fission yeast.
Kungase kubonakale kungenangqondo ukuthi i-apoptosis-inducing compound inganweba isikhathi sempilo yento ephilayo, kodwa u-Emami wachaza ukuthi i-DIM ibonakala ikhuthaza lokhu kuziphatha ekuhlukaniseni amaseli ngokusobala, njengamaseli omdlavuza. Uma befa, umzimba ungaphila isikhathi eside.
"Ucwaningo lwakamuva kubantu lubonisa ukuthi i-DIM iyisidakamizwa esingase sinqande umdlavuza esenza ngokudala i-apoptosis ezinhlotsheni ezihlukahlukene zomdlavuza, kuhlanganise nomdlavuza webele, we-prostate, wesisu nowe-pancreatic," kusho u-Ueno.
“Ucwaningo luphinde luveze ukuthi i-DIM idala i-autophagy kumaseli omdlavuza. Kodwa-ke, umphumela we-autophagy ekwakhekeni kwesimila nokuqhubeka kwawo awuqondwa ngokugcwele. Ukuqonda indlela ye-apoptosis kanye ne-autophagy ngokusebenzisa i-DIM kumvubelo ye-fission kungase kube usizo ocwaningweni ngomdlavuza womuntu kanye nezindlela zokuphila isikhathi eside. "
Abacwaningi bazoqhubeka nokufunda indima ye-DIM kumvubelo we-fission.
"Sifuna ukuqonda ukuthi i-DIM ilimaza kanjani ulwelwesi lwe-fission yeast nuclear, okungaholela ekwakhiweni kwesidakamizwa esisezingeni lokuqala sokubulala amangqamuzana omdlavuza," kusho u-Emami.
"Sifuna nokuqonda indlela i-DIM eyenza ngayo i-autophagy ku-fission yeast, engaba nomthelela ekuqondeni indlela yokwandisa isikhathi sokuphila komuntu."